The value of Gd-EOB-DTPA enhanced MRI radiomics and signal intensity in hepatobiliary phase in predicting the degree of pathological differentiation of hepatocellular carcinoma
10.3969/j.issn.1002-1671.2025.07.017
- VernacularTitle:钆塞酸二钠增强MRI影像组学及肝胆期信号强度预测肝细胞癌病理分化程度的价值
- Author:
Kaiying WU
1
;
Yixing YU
;
Zhu ZHU
;
Dabo XU
;
Sunxian DAI
;
Wei FANG
;
Xinyu LU
;
Ximing WANG
;
Chunhong HU
;
Wenhao GU
Author Information
1. 苏州大学附属太仓医院放射科,江苏 苏州 215400
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
hepatobiliary phase;
signal intensity;
radiomics;
pathological differentiation degree;
gad-olinium ethoxybenzyl diethylenetriamine pentaacetic acid
- From:
Journal of Practical Radiology
2025;41(7):1158-1162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced MRI radiomics and signal intensity in hepatobiliary phase(HBP)in predicting the pathological differentiation degree of hep-atocellular carcinoma(HCC).Methods The clinical and imaging data of 224 patients pathologically confirmed with HCC were col-lected.All patients were randomly divided into test group(68 cases)and training group(156 cases)at a ratio of 7︰3.The ITK-SNAP software was used to delineate region of interest(ROI)on arterial phase(AP),portal venous phase(PVP)and HBP,the radiomics features of the tumor tissues were extracted and the radiomics models were established using the FAE software.Logistic regression analysis was used to determine the clinical independent predictors associated with the pathological differentiation degree of HCC and to construct clinical model and clinical-radiomics model.Receiver operating characteristic(ROC)curve was plotted for each model and the area under the curve(AUC)was calculated to compare the diagnostic efficacy of the models.Results Age,alpha-fetoprotein(AFP),and r-glutamyltransferase(r-GT)were independent risk factors for predicting the degree of pathological differentiation of HCC.The AUC of the clinical-radiomics model in the training group and test group were 0.825 and 0.779,respectively,which were higher than those of the radiomics model(0.812 and 0.771)and the clinical model(0.687 and 0.666).Conclusion Gd-EOB-DTPA enhanced MRI radiomics have certain value in predicting the degree of pathological differentiation of HCC,while the predictive value of the signal intensity on HBP and the signal intensity ratio(SIR)on HBP is limited.
