Study of the effects of rapid short-term plateau exposure on thyroid related hormone parameters in healthy male pilots
10.3760/cma.j.cn113854-20240510-00074
- VernacularTitle:急进高原短期暴露对健康男性飞行员甲状腺相关激素参数影响的研究
- Author:
Wenzhuo ZHU
1
;
Xi ZHU
1
;
Zehong PENG
1
;
Jianglong WEN
1
;
Na DAI
1
;
Chao LIU
1
;
Lili ZHU
1
Author Information
1. 联勤保障部队第九二一医院全科医学科，长沙 410003
- Publication Type:Journal Article
- Keywords:
Thyroid gland;
Hypoxia;
Rapid advance in the short term;
High altitude exposure;
Pilots
- From:
Chinese Journal of Aerospace Medicine
2024;35(4):294-297
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of rapid short-term altitude exposure on thyroid related hormone parameters in healthy male pilots.Methods:A total of 132 healthy male pilots who lived in the plain were selected by random number table method to enter the plateau, with an average altitude of 3 000 m, within 3 h by plane from the plain, with an average altitude of 100 m, from March 2023 to April 2023, and returned to the plain within 3 h by plane 15 d later. General physiological indices, thyroid related hormone parameters [thyroid stimulating hormone (TSH), total thyroid hormone (TT 4), free thyroxine (FT 4), free triiodothyronine (FT 3), total triiodothyronine (TT 3), thyroglobulin antibody (TgAb), anti-thyroid peroxidase antibody (TPOAb), and thyroglobulin (Tg)] were collected from the pilots 1 day before the rush into plateau exposure and after 15-day plateau exposure. The differences in thyroid related hormone parameters of the pilots before and after acute short-term plateau exposure were compared. Results:As compared with the parameters before entering the plateau, the heart rate, respiratory rate, systolic and diastolic blood pressure of pilots were increased and oxygen saturation was decreased after 15 d plateau exposure, and the differences were statistically significant ( t=8.65, 10.78, 13.39, 12.49, 17.72, all P<0.001). The levels of TSH, FT 4, TPOAb and Tg of pilots were all decreased after 15 d plateau exposure, and the differences were significant ( t=3.67, 2.17, Z=-4.63, -7.49, P=0.003, 0.049, <0.001, <0.001). The levels of TT 4 and TT 3 were elevated, with significant differences ( t=4.08, 2.55, P<0.001, =0.024). TgAb level was less discrete, but the difference was significant ( Z=-2.36, P=0.018). Conclusions:By rush into plateau and short-term exposure, the healthy male pilots showed decreased TSH, FT 4, TPOAb and Tg, and increased TT 4 and TT 3, and those may result in the thyroid gland due to acute stress and low-pressure hypoxia appeared related to the hormone metabolism and protein changes.
