The value of 18F-fluorodeoxyglucose PET/CT in predicting the stage of elderly esophageal cancer
10.3969/j.issn.1002-1671.2025.07.008
- VernacularTitle:18氟-氟代脱氧葡萄糖PET/CT预测老年食管癌分期的价值
- Author:
Yan ZHENG
1
;
Xiaozheng CAO
1
;
Ping CHEN
1
;
Cheng HUANG
1
Author Information
1. 河南科技大学临床医学院 河南科技大学第一附属医院核医学科,河南 洛阳 471003
- Publication Type:Journal Article
- Keywords:
esophageal cancer;
18F-fluorodeoxyglucose;
pos-itron emission tomography/computed tomography
- From:
Journal of Practical Radiology
2025;41(7):1114-1118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of 18F-fluorodeoxyglucose(18F-FDG)PET/CT in predicting the stage of untreated elderly esophageal cancer.Methods The clinical data of 83 esophageal cancer patients who had not received any treatment were ret-rospectively analyzed,including age,body mass index(BMI),lesion length and width,TNM stage,and clinical stage.Spearman correlation analysis was used to evaluate the correlation between TNM stage and clinical stage and the maximum standardized uptake value(SUVmax)of the primary tumor.Linear correlation analysis was used to evaluate the correlation between age,BMI,lesion length and width,and SUVmax.The receiver operating characteristic(ROC)curve of the primary tumor SUVmax in predicting the newly diagnosed elderly esophageal cancer T3-T4 stage and clinical stage Ⅲ-Ⅳ was plotted,the area under the curve(AUC)was obtained,and the best cut off value of the primary tumor SUVmax in the diagnosis of T3-T4 stage and clinical stage Ⅲ-Ⅳ was obtained.Results The T stage and clinical stage were positively correlated with the SUVmax of the primary tumor(r=0.688,P<0.001;r=0.313,P=0.004),while the N stage,M stage,lesion location,age,BMI,lesion length and width were not correlated with the SUVmax(P>0.05).There were significant differences in SUVmax between the T1-T2 stage and the T3-T4 stage,as well as between the clinical stageⅠ-Ⅱ and the Ⅲ-Ⅳ(P<0.05).According to the analysis of ROC curve,the AUC for diagnosing T3-T4 stage and clinical stageⅢ-Ⅳ with the SUVmax of the primary tumor were 0.904[95%confidence interval(CI)0.835-0.973]and 0.700(95%CI 0.570-0.829),respectively,with cut off values of 12.40 and 12.70.The sensitivities were 0.918 and 0.708,respectively,and the specificities were 0.712 and 0.729,respectively.Conclusion 18F-FDG PET/CT primary tumor SUVmax has a good predictive value for the diagnosis of untreated elderly esophageal cancer before treatment of T3-T4 stage and clinical stage Ⅲ-Ⅳ,which can improve the accuracy of esophageal cancer stage.
