Clinical and diffusion imaging study of brain damage in patients with neurosyphilis
10.3969/j.issn.1002-1671.2025.07.006
- VernacularTitle:神经梅毒患者脑损害的临床与扩散成像研究
- Author:
Yuwen XIE
1
;
Ruiyun ZHAO
;
Pingping WANG
Author Information
1. 青海省第四人民医院放射科核磁室,青海 西宁 810007
- Publication Type:Journal Article
- Keywords:
neurosyphilis;
brain damage;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2025;41(7):1104-1108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and diffusion imaging of brain damage in patients with neurosyphilis.Methods Eighty patients with neurosyphilis with brain damage were retrospectively selected as the study group,and were divided into mild group(n=38)and moderate to severe group(n=42)according to imaging results.Another 80 healthy subjects in the same period were selected as the control group.The values of apparent diffusion coefficient(ADC)and fractional anisotropy(FA)were compared among the three groups.Pearson test was used to analyze the correlation between ADC and FA values in various brain regions and cognitive function in patients with neurosyphilis brain damage.Results ADC values in parieto-occipital lobe,frontal lobe,basal gan-glia and hemioval center in moderate to severe group were significantly higher than those in mild group and control group,and FA values were significantly lower than those in mild group and control group(P<0.05).The results of Pearson analysis showed that the ADC and FA values of parieto-occipital lobe,frontal lobe and hemioval center were significantly correlated with Wechsler adult intel-ligence scale-revised of China(WAIS-RC)knowledge,WAIS-RC arithmetic,verbal fluency test(VFT),Montreal cognitive assess-ment(MoCA),forward digit span test(FDST),trail making test A(TMT-A)and trail making test B(TMT-B)scores(P<0.05).Conclusion The ADC and FA values of parieto-occipital lobe,frontal lobe,basal ganglia and hemioval center are closely related to the severity of brain damage,which is helpful for clinical diagnosis.
