Anti-Skin Photoaging Activity and Mechanism Analysis of Total Flavonoids from the Chinese Herb Tulip
- VernacularTitle:中药郁金香总黄酮的抗皮肤光老化活性评价及机制分析
- Author:
Jiafeng YE
1
;
Jiamin CAO
1
;
Wei LI
1
;
Yuewen MA
1
;
Chunli WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: The Chinese herb tulip; Flavonoid; Skin photoaging; Network pharmacology; Molecular simulation
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(7):2000-2012
- CountryChina
- Language:Chinese
- Abstract: Objective To assess the anti-skin photoaging properties of total flavonoids(TFT)extracted from the Chinese herb tulip,a preliminary analysis of its mechanism in combating skin photoaging were conducted.Methods UVB-induced photoaging mouse model was used to assess the anti-skin photoaging effects of TFT.A network pharmacology approach was used to conduct a preliminary analysis of TFT's mechanism of action against skin photoaging.Furthermore,molecular simulation was employed to predict the interactions between the active ingredients and target proteins.Results Treatment with TFT effectively improved skin condition in UVB-induced photoaging mice.The mechanism of action of TFT against skin photoaging likely involved the regulation of transcription factors such as NF-κB and AP-1,modulation of SASPs transcription,and inhibition of MMPs activity.Conclusion TFT is an effective anti-skin photoaging ingredient that deserves further research and development.
