Mechanism of Notch signaling pathway regulating condylar cartilage development and temporomandibular joint inflammation
- VernacularTitle:Notch信号通路调控髁突软骨发育及颞下颌关节炎症的作用机制
- Author:
Xingqi AN
1
;
Wenjin LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Notch signaling pathway; condylar cartilage; condylar chondrocytes; temporomandibular joint; temporomandibular joint inflammation; craniomaxillofacial skeleton; pathway mechanism; engineered tissue construction
- From: Chinese Journal of Tissue Engineering Research 2025;29(26):5673-5679
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:The condyle is the most important anatomical structure of the maxillofacial region,and it plays an important role in mastication and articulation of the human body,and its developmental process is quite different from that of the general bone tissues.Abnormal development of the condylar cartilage can lead to various temporomandibular joint disorders to varying degrees,which affects the patient's quality of life.Abnormal conduction of Notch signaling not only influences the developmental process of the condylar cartilage,but also leads to a series of related diseases such as temporomandibular joint disorders.Aberrant Notch signaling not only affects condylar cartilage development and formation,but also leads to a series of related diseases such as temporomandibular joint disorders.However,the role of Notch signaling pathway in condylar cartilage development and temporomandibular joint disorders has not been fully elucidated.OBJECTIVE:To deeply investigate the mechanism of Notch and condylar cartilage growth and development,and discuss the core of Notch as a therapeutic target for temporomandibular joint arthritis.METHODS:We retrieved,searched and screened relevant literature in CNKI and PubMed with the keywords"Notch signaling pathway,condylar chondrocyte,condylar cartilage,temporomandibular arthritis"in Chinese and English respectively to provide a theoretical basis for the full text.Using comparative analysis method,we compared the retrieved literature,excluded the literature with similar content,compared the differences between the screened literature,and selected the content needed for this article,providing the theoretical basis for the writing of the article.By further studying and analyzing the screened literature,the mechanism of action between the factors was clarified to provide a clear idea for the article.A total of 1 848 relevant papers were retrieved and 53 papers were finally included for review.RESULTS AND CONCLUSION:(1)The condylar cartilage grows and develops in a more complex manner than other bones,and it undergoes an endochondral osteogenesis.Condylar chondrocyte differentiation is susceptible to a variety of factors,which ultimately affects the formation of cartilage and osteoblasts.(2)The Notch signaling pathway has attracted much attention in recent years,and plays a very important role in condylar growth and development.(3)The Notch signaling pathway consists of four components:four Notch receptors(Notch 1-4),five Notch ligands(JAG 1/2 and DLL 1/3/4),intracellular transcription factors(CSL-binding proteins),and multiple target genes such as Hes and Hey.The Notch signaling pathway is divided into two main pathways:typical pathway and atypical pathway.(4)The Notch signaling pathway is interfered with by factors such as y-secretase inhibitors or parathyroid hormone-related proteins in vivo,and common factors such as receptors and ligands are expressed abnormally,thus affecting condylar cartilage growth and development.(5)In addition to the various factors in the body,abnormal masticatory stress and excessive loading of the temporomandibular joint can also affect the normal transmission of the Notch signaling pathway,resulting in the abnormal development of the condylar cartilage.(6)The Notch signaling pathway also affects temporomandibular joint arthritis,and the abnormal signaling can affect the pathogenesis of temporomandibular joint arthritis.
