The Acceleration of Spatial Navigation Aging Process by Liver Failing to Convey and Disperse and Its Neuroelectrophysiological Mechanisms
- VernacularTitle:肝失疏泄加速空间导航老化进程及神经电生理机制
- Author:
Yan ZHANG
1
;
Yong LIU
;
Lan ZHAO
;
Jinchai DENG
;
Lei HUO
;
Zhongpeng QIN
;
Wenju ZHANG
;
Xianghong ZHAN
Author Information
- Publication Type:Journal Article
- Keywords: Event-related potentials; Space navigation; Neuroticism; Liver failing to convey and disperse
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(7):1934-1945
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the influence of the liver failing to convey and disperse on space navigation aging.Methods High and low neuroticism subjects screened by Eysenck personality questionnaire were included in liver failing to convey and disperse group and liver controlling conveyance and dispersion group,respectively.The two groups were then divided into youth and elderly groups based on age.Finally,spatial navigation task was conducted to record and analyze behavioral(reaction time and accuracy)and EEG data(amplitude and latency of P2 and N2 components)of all the four groups(30 subjects each group).Results Compared with liver controlling conveyance and dispersion group,the accuracy in subjects with liver failing to convey and disperse decreased significantly(P<0.001)and reaction time was prolonged significantly(P<0.05).The interaction effect between age and liver regulation status showed a marginal significant difference(P=0.078).The accuracy of elderly people was lower than that of youth people(P=0.002)for liver failing to convey and disperse subjects,while there was no significant difference between the two groups for subjects with liver controlling conveyance and dispersion.The P2 amplitude in the elderly group was significantly smaller than that in the youth group(P=0.027).The amplitude of P2 in group of liver failing to convey and disperse was significantly smaller than that in group of liver controlling conveyance and dispersion(P=0.042).The interaction effect of P2 amplitude between age and liver regulation status showed a marginal significance(P=0.073).For youth subjects,the P2 amplitude in group of liver controlling conveyance and dispersion was significantly larger than that in group of liver failing to convey and disperse(P=0.007),while there was no significant difference in P2 amplitude between the two groups for the elderly subjects.The N2 amplitude for tasks of allocentric frames of reference was significantly greater than that of egocentric frames of reference(P=0.024).Conclusion Liver failing to convey and disperse caused by long-term emotional disturbance accelerates spatial navigation aging,and selective attention feature inhibition disorder may be the underlying ERPs neuroelectrophysiological mechanism.
