Evaluation of Characteristics of Animal Models of Leukemia Based on Data Mining
10.11842/wst.20240905004
- VernacularTitle:白血病动物模型特点及应用分析
- Author:
Linjing SHE
1
;
Bingcong QU
1
;
Tianbao ZHOU
1
;
Lin GUO
1
;
Yixuan XIE
1
;
Ming BAI
1
;
Mingsan MIAO
1
Author Information
1. 河南中医药大学 郑州 450046
- Publication Type:Journal Article
- Keywords:
Leukemia;
Animal models;
Evaluation indicators;
Data mining
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(7):1914-1921
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide a reference basis for the establishment of ideal animal models of leukemia,the characteristics of animal models of leukemia was summarized.Methods The themes of"leukemia"and"animal"were searched in CNKI databases.The relevant literature on animal experiments of leukemia from January 2010 to August 2024 were screened.And a database by Excel 2017 tables was established by organizing their research animal strains,modeling methods and testing indexes to analyze the characteristics of leukemia animal models.Results After comparative analysis,it was found that the animal strains in modeling were BALB/C-nude mice(40 times,29.86%)and NOD/SCID mice(32 times,23.88%),respectively.The modeling method was transplanted cells(127 times,93.38%),and the detection indexes were pathological tissues(80 times,14.84%),blood smears(75 times.13.91%),general condition(73 times,13.54%),bone marrow smear(73 times,13.54%),flow cytometry(55 times,10.20%),blood routine(50 times,9.28%).Conclusion The existing animal models of leukemia are complex and diverse.
