Mitochondrial dysfunction and brain aging:a bibliometrics analysis based on the Web of Science Core Collection database
10.12307/2025.688
- VernacularTitle:线粒体功能障碍与脑衰老:Web of Science核心数据库来源文献的计量学分析
- Author:
Songhua NAN
1
;
Chaojie PENG
;
Yinglin CUI
Author Information
1. 河南中医药大学,河南省郑州市 450000
- Publication Type:Journal Article
- Keywords:
brain aging;
mitochondrial dysfunction;
oxidative stress;
Alzheimer's disease;
Parkinson's disease;
central nervous system;
CiteSpace;
bibliometric analysis;
big data analysis
- From:
Chinese Journal of Tissue Engineering Research
2025;29(26):5642-5651
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:With the rapid development of the biomedical field in recent years,research on brain aging and mitochondrial dysfunction has gradually become an academic hotspot.However,there has yet to be a systematic bibliometric analysis in this field.OBJECTIVE:To comprehensively analyze the research progress in the field of brain aging and mitochondrial dysfunction,and review and summarize relevant literature in the past 20 years,aiming to reveal the current research status,hotspots,and development trends in this field.METHODS:Using the Web of Science Core Collection database as a literature search platform,all documents related to brain aging and mitochondrial dysfunction published from the database inception to May 7,2024 were collected.The CiteSpace 6.3.R1 visualization analysis tool was used to conduct a multi-dimensional in-depth analysis of the collected literature data,including country,institution,author,keywords,and co-cited literature,in order to reveal the research dynamics and cutting-edge hotspots in this field.RESULTS AND CONCLUSION:This study included 2 534 relevant documents and the number of publications in this field has been yearly increasing both domestically and internationally.The country with the highest number of publications is the United States(974 articles),followed by China(362 articles).At the institutional level,the University of California in the United States ranks first in terms of publication volume(117 articles).In terms of personal contributions,Professor Reddy P.Hemachandra from the Texas Tech Center for Health Sciences is the most prolific scholar in the field,while Professor Mattson MP from the National Institute on Aging in the United States is the most cited scholar.INT J MOL SCI is the most prolific journal in this field.High-frequency keywords include"oxidative stress,""mitochondrial dysfunction,""Alzheimer's disease,"and"Parkinson's disease."By analyzing the cutting-edge hotspots in this field,it was found that the focus of research has gradually shifted from the exploration of molecular mechanisms to the search for biomarkers that can be used for the early identification and diagnosis of neurodegenerative diseases.In addition,mitochondrial dysfunction is expected to serve as a clinical interventional target for brain aging-related neurodegenerative diseases.
