Correlation between hemoglobin A1c levels and excessive daytime sleepiness in type 2 diabetes mellitus patients
10.3969/j.issn.1006-6187.2025.07.003
- VernacularTitle:2型糖尿病患者糖化血红蛋白水平与日间思睡相关性的研究
- Author:
Yang LIU
1
;
Mengyuan NI
;
Cong LIU
;
Zhaomin LU
;
Zhiye WANG
;
Zuonian ZHANG
;
Wei WANG
;
Lihua ZHANG
;
Junjun LIU
Author Information
1. 210039 南京梅山医院神经内科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Excessive daytime sleepiness;
Hemoglobin A1c
- From:
Chinese Journal of Diabetes
2025;33(7):492-496
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between hemoglobin A1c(HbA1c)levels and excessive daytime sleepiness(EDS)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 132 T2DM patients and 40 healthy people(NC group)who were treated in the outpatient department of Nanjing Meishan Hospital from December 2020 to December 2022 were selected.General clinical data of the subjects were collected,and their Epworth sleepiness scale(ESS)scores,Pittsburgh sleep quality index(PSQI),and apnea-hypopnea index(AHI)were measured.Based on ESS scores,T2DM patients were divided into simple T2DM group(ESS score<9,n=99)and EDS group(ESS score≥9,n=33)according to ESS score.The baseline data were compared for each group.Spearman correlation analysis and multivariate logistic regression model were used to evaluate the correlation between HbA1c levels and EDS.The receiver operating characteristic(ROC)curve was used to calculate the area under the curve(AUC)to evaluate the predictive value of HbA1c levels for EDS.Results HbA1c,fasting plasma glucose,AHI index and PSQI score in EDS group were higher than those in T2DM and NC group(P<0.05).Spearman correlation analysis showed that ESS score was positively correlated with HbA1c in T2DM patients(P<0.05).Multivariate logistic regression analysis revealed that elevated HbA1c levels emerged as a significant and independent risk factor for the onset of EDS.The ROC curve indicated that the AUC of HbA1c for predicting EDS was 0.736.Conclusions There is an independent positive correlation between HbA1c levels and EDS in T2DM patients,which provides clues for early identification and treatment of EDS in clinical practice.
