Plant-derived exosome-like nanovesicles stimulate osteoblasts,inhibit osteoclasts,and promote osteogenesis
- VernacularTitle:植物源外泌体样纳米囊泡刺激成骨细胞、抑制破骨细胞并促进成骨
- Author:
Wenxin YAO
1
;
Yi WANG
;
Lin CAI
;
Xiaobo FENG
Author Information
- Publication Type:Journal Article
- Keywords: osteoporosis; plant-derived exosome-like nanovesicle; exosome; osteoblast; osteoclast; engineered exosome
- From: Chinese Journal of Tissue Engineering Research 2025;29(31):6765-6771
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Osteoporosis affects the quality of life of patients and is prone to pathological fractures,and plant-derived exosome-like nanovesicles play an important role in regulating bone balance in patients with osteoporosis.OBJECTIVE:To review the research status and prospect of different plant-derived exosome-like nanovesicles in the treatment of osteoporosis.METHODS:Relevant literature in PubMed,Web of Science,and CNKI databases were searched by computer.Search time was from January 1995 to March 2024.The Chinese and English search terms were"osteoporosis,plant-derived exosome-like nanovesicles,exosomes,osteoblasts,osteoclasts."Finally,53 articles were included and analyzed.RESULTS AND CONCLUSION:Plant-derived exosom-like nanovesicles have the advantages of low biocompatibility,low toxicity,and natural targeting.These properties not only ensure its stable presence and effective effect in the body,but also avoid unnecessary immune responses,laying the foundation for the design of long-term treatment strategies.Plant-derived exosome-like nanovesicles can be anti-osteoporosis by stimulating osteoblast proliferation,inhibiting osteoclast differentiation,and promoting osteo-inhibition osteoclasts.In addition,some plant-derived exosome-like nanovesicles may be widely used in the diagnosis and treatment of osteoporosis in the future as novel tracer targets and treatment options due to their bone-targeting.
