Correlation analysis of serum cystatin C and renal blood flow parameters in 347 pilots
10.3760/cma.j.cn113854-20230509-00044
- VernacularTitle:347名飞行员血清胱抑素C与肾血流参数的相关性分析
- Author:
Yuhui ZHU
1
;
Rui HAN
;
Xiaohui ZHENG
;
Qiaolian ZHANG
;
Weibo SHI
;
Ying ZHU
;
Yingkun XIE
Author Information
1. 联勤保障部队第九六〇医院干部病房，济南 250031
- Publication Type:Journal Article
- Keywords:
Renal circulation;
Serum;
Cystatin C;
Pilots
- From:
Chinese Journal of Aerospace Medicine
2024;35(1):23-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To provide warning information for early renal injury in pilots by investigating the relationship between serum cystatin C (Cys-C) level and renal blood flow parameters in healthy pilots.Methods:A total of 347 military pilots who underwent annual physical examination in the Air Service Department of the 960th Hospital of Joint Logistics Support Force from July of 2019 to December of 2021 were selected as the pilot group, and 347 healthy subjects who were in same age span and examined at same period were selected as the control group. Color Doppler flow imaging was used to qualitatively analyze renal artery blood flow parameters, including the peak systolic velocity (PSV), end-diastolic blood flow velocity (EDV) and resistance index (RI) of the main renal artery, segmental artery and interlobar arteries. The serum urea nitrogen, serum creatinine and uric acid of subjects were measured. Both pilot group and the control group were divided into 21-30 years old, 31-40 years old and 41-50 years old groups. According to the median level of serum Cys-C, the pilots were divided into high Cys-C group and low Cys-C group. The Cys-C level and renal blood flow parameters of each group were compared, and the correlation between Cys-C level and renal blood flow parameters of pilots was analyzed.Results:There were no significant differences on serum Cys-C level between the pilot group and the control group at all ages (all P>0.05). There was a significant difference on Cys-C levels among the pilots of different ages ( H=8.24, P=0.045). There was no significant difference in Cys-C levels among control groups at different ages ( P>0.05). The levels of endogenous creatinine clearance and uric acid in the high Cys-C group were higher than those in the low Cys-C group, and the differences were significant ( Z=-4.17, -2.98, P<0.001, =0.003). The EDV of main renal artery in high Cys-C group was lower than that in low Cys-C group, and the difference was significant ( t=4.82, P=0.021). The EDV of interlobar arteries in high Cys-C group was lower than that in low Cys-C group, and the difference was significant ( Z=-5.48, P=0.030). Correlation analysis showed that the Cys-C level of pilots was positively correlated with age, flying hours and uric acid level ( r=0.381, 0.165, 0.359, P=0.001, 0.002, 0.003). Cys-C level was negatively correlated with EDV of main renal artery and interlobar arteries ( r=-0.306, -0.321, P=0.048, 0.024), and positively correlated with RI of main renal artery ( r=0.417, P=0.029). Conclusions:The serum Cys-C of pilots could reflect certain basic data of renal function and is hopeful to provide warning for early renal injury due it correlated to the EDV of main renal artery and interlobar arteries and the RI of main renal artery.
