Investigation of pharmacokinetic variation in hemophilia A patients and clinical case reports of individual-ized rehabilitation training
10.3969/j.issn.1001-1242.2025.07.012
- VernacularTitle:血友病A患者药代动力学参数初步评估与个体化康复训练临床疗效评价
- Author:
Zhiming HUANG
1
;
Haoqing JIANG
1
Author Information
1. 福建省漳州市医院康复医学科,福建省 漳州市,363000
- Publication Type:Journal Article
- Keywords:
hemophilia A;
pharmacokinetics;
coefficient of variation;
knee joint
- From:
Chinese Journal of Rehabilitation Medicine
2025;40(7):1052-1056
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the variation of pharmacokinetic(PK)distribution after transfusion of coagulation fac-tor Ⅷ.(FVⅢ.)in patients with hemophilia,and to explore the clinical application of individualized rehabilita-tion training.Method:Thirteen patients diagnosed with hemophilia A were enrolled from March 2021 to May 2022.The dis-tribution characteristics of PK parameters after FVⅢ.were monitored and calculated by myPKFiT software.Indi-vidualized rehabilitation training guidance was carried out according to the individual characteristics of patients.The improvement of annual bleeding rate(ABR),annual joint bleeding rate(AJBR),Hemophilia joint health score(HJHS)and functional independence measure(FIM)score after rehabilitation training was evaluated.Result:The mean and 95%CI of clearance,steady-state distribution volume,half time were 0.03(0.02-0.03)dL/hr/kg,0.49(0.46-0.52)dL/kg,14.05(12.19-15.92)hours,respectively.The coefficients of variation(CV)of clearance,steady-state distribution volume,half time were 23.93%,10.03%and 21.97%,respective-ly.The results of the Wilcoxon signed-rank test indicated that clinical symptoms such as ABR,AJBR,HJHS and FIM were significantly improved after rehabilitation training(P<0.05).Conclusion:The distribution of pharmacokinetics of hemophilia patients shows an uneven distribution between indi-viduals,and individualized rehabilitation training can further improve the joint symptom score of hemophilia patients.
