Recent advance in mechanisms of hypothalamic regulating chronic migraine and its comorbidities
10.3760/cma.j.cn115354-20240922-00588
- VernacularTitle:下丘脑调控慢性偏头痛及其合并症的机制研究进展
- Author:
Junyou GONG
1
;
Xianghan DUAN
;
Jiejie HU
;
Hongbin CAI
;
Zhaoming GE
Author Information
1. 兰州大学第二医院神经内科，兰州 730000
- Publication Type:Journal Article
- Keywords:
Chronic migraine;
Hypothalamus;
Comorbidity;
Pathogenic mechanism
- From:
Chinese Journal of Neuromedicine
2025;24(4):428-432
- CountryChina
- Language:Chinese
-
Abstract:
Chronic migraine is a common episodic brain dysfunction disorder, which often progresses from migraine and is frequently accompanied by sleep disorders, anxiety, depression or obesity. Extensive connections exist between the hypothalamus and other components of the central nervous system; through integrating pain signals, neural conduction and inflammatory pathways, the hypothalamus becomes an important hub for migraine chronicization. This review, combined with clinical imaging evidence, analyzes the pathogenic mechanisms of chronic migraine and its complications from perspective of the hypothalamus as the higher neural center, so as to provide useful references for prevention and treatment of chronic migraine.
