Multimodal MRI-based neurophenotype correlated to structural bowel damage in Crohn's disease
10.3969/j.issn.1006-5725.2025.15.016
- VernacularTitle:多模态MRI表征的神经表型与克罗恩病肠道损伤的相关性
- Author:
Zhuangnian FANG
1
;
Ruonan ZHANG
1
;
Lili HUANG
1
;
Xiaodi SHEN
1
;
Qingzhu ZHENG
1
;
Yangdi WANG
1
;
Xuehua LI
1
;
Zhoulei LI
1
;
Shaochun LIN
1
Author Information
1. 中山大学附属第一医院放射科(广东 广州 510080)
- Publication Type:Journal Article
- Keywords:
Crohn's disease;
brain-gut axis;
bowel damage;
Lémann index
- From:
The Journal of Practical Medicine
2025;41(15):2398-2405
- CountryChina
- Language:Chinese
-
Abstract:
Objective To characterize neurological alterations associated with structural bowel damage in patients with Crohn's disease(CD)through radiomics-assisted neurophenotyping,utilizing multiparametric brain MRI.Methods This prospective study enrolled patients with CD who underwent brain MRI,MR enterography,and ileocolonoscopy within one week.The Lémann Index was used to quantitatively assess cumulative structural bowel damage.CD patients were stratified into two groups based on a cutoff value of 4.8:those with bowel damage(LI>4.8)and those without bowel damage(LI≤4.8).A neurophenotype model was developed to characterize the neural changes associated with bowel damage in CD.Key features were selected from first-order features extracted from multiparametric brain MRI in the training cohort and validated in an independent test cohort.Results The final study population comprised 109 patients,including 51 individuals with bowel damage and 58 without bowel damage.The neurophenotype model scores were 0.785(95%CI:0.506～0.945)in the bowel damage group and 0.155(95%CI:0.093～0.394)in the non-bowel damage group,showing a statistically significant difference between the two groups(P<0.001).The developed model exhibited strong discriminative performance,with area under the receiver operating characteristic curve(AUC)values ranging from 0.824 to 0.918 across the training,vali-dation,and test cohorts(all P<0.05).Conclusion Our radiomics-assisted neurophenotype analysis reveals neural alterations in CD patients with bowel damage,which may indicate extraintestinal manifestations associated with cumulative intestinal injury.
