Progress in role and intervention of M2 microglia in ischemic stroke
- VernacularTitle:M2小胶质细胞在缺血性脑卒中的作用及干预的研究进展
- Author:
Si-rou WANG
1
;
Qian ZHANG
;
Guo-jian ZHAO
;
Meng-jie ZHANG
;
Zhi-hua HUANG
Author Information
- Publication Type:Journal Article
- Keywords: ischemic stroke; M2 microglia; neuroinflammation; neurogenesis; drug; intervention
- From: Chinese Pharmacological Bulletin 2025;41(3):411-416
- CountryChina
- Language:Chinese
- Abstract: Stroke is one of the main diseases that threaten human health,including ischemic stroke and hemorrhagic stroke,with the former being the main cause.The important pathogenesis of ischemic stroke includes neuroinflammation,oxidative stress,and excitatory toxic damage,and neuroinflammation plays an impor-tant role in the pathogenesis and rehabilitation process of ische-mic stroke.Microglia are inherent immune cells in the central nervous system,which monitor the site of injury and respond to the immune response as soon as a stroke occurs.The activated microglia are mainly polarized into pro-inflammatory M1 type and anti-inflammatory M2 type.The latter improves neurological dys-function by inhibiting neuroinflammation,promoting neuronal re-generation and myelin repair,and maintaining the integrity of the blood-brain barrier.It suggests that it may be a potential target for treating ischemic stroke by combating acute phase injury and promoting chronic phase rehabilitation.Precise regulation of M1/M2 activation has important therapeutic value in cerebral protection in ischemic stroke.This article focuses on the role of M2 microglia in ischemic stroke and the mechanism of various drugs or acupuncture and moxibustion therapy regulating the transformation of microglia into M2 type,in order to provide theo-retical basis for clinical treatment of stroke and new drug devel-opment.
