Changes of brain excitation/inhibition balance and gray matter volume and their correlations with clinical features in benign childhood epilepsy with centrotemporal spikes
10.3760/cma.j.cn115354-20250124-00045
- VernacularTitle:伴中央颞区棘波的儿童良性癫痫脑皮层结构发育、兴奋/抑制平衡的变化及二者与临床特征的关系研究
- Author:
Xinhe YAO
1
;
Qiang XU
;
Yiwen CHEN
;
Qirui ZHANG
;
Jianrui LI
;
Zhaojie WANG
;
Yuzhuo LI
;
Fang YANG
;
Yan HE
;
Chunfeng WU
;
Gang YANG
;
Guangming LU
;
Zhiqiang ZHANG
Author Information
1. 南京大学医学院附属金陵医院放射诊断科，南京 210002
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Children;
Brain excitatory/inhibitory balance;
Hurst index;
Gray matter volume
- From:
Chinese Journal of Neuromedicine
2025;24(4):378-384
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the changes of brain excitation/inhibition balance and gray matter volume (GMV) and their correlations with clinical features in benign childhood epilepsy with centrotemporal spikes (BECTS).Methods:A cross-sectional study was performed; 83 BECTS children enrolled from Department of Diagnostic Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University from January 2015 to January 2024 were selected as BECTS group. During the same period, 101 age- and gender-matched healthy children were recruited as healthy control group through advertisements in local primary schools. Data of conventional MRI and resting-state functional MRI (rs-fMRI) of the two groups were collected. Whole brain GMV was analyzed by voxel-based morphometry (VBM), and Hurst index was calculated based on time series data of blood oxygen level dependent (BOLD) signal of rs-fMRI. Correlations of GMV and Hurst index with disease duration and onset age in children with BECTS were explored by Pearson correlation analysis.Results:Compared with the healthy control group, the BECTS group had significantly increased GMV and decreased Hurst index in the bilateral Rolandic region ( P<0.05). Pearson correlation analysis showed that in the BECTS group, GMV in bilateral Rolandic region was negatively correlated with onset age ( r=-0.267, P=0.015) and positively correlated with disease course ( r=0.267, P=0.015); Hurst index in bilateral Rolandic region was positively correlated with onset age ( r=0.323, P=0.003) and negatively correlated with disease course ( r=-0.240, P=0.029); Hurst index was negatively correlated with GMV in bilateral Rolandic region ( r=-0.328, P=0.003). Conclusion:BECTS children have excitation/inhibition imbalance in epilepsy-related regions and cortical structural delay, and both of them are related to onset age and disease course.
