Recent advance in application of single-cell transcriptome sequencing in central nervous system diseases
10.3760/cma.j.cn115354-20241025-00651
- VernacularTitle:单细胞转录组测序技术在中枢神经系统疾病中的应用研究进展
- Author:
Xinting LIU
1
;
Guang YANG
1
Author Information
1. 解放军总医院第七医学中心儿科医学部，北京 100700
- Publication Type:Journal Article
- Keywords:
Central nervous system disease;
Single-cell RNA sequencing;
Diagnosis;
Therapy
- From:
Chinese Journal of Neuromedicine
2025;24(3):286-292
- CountryChina
- Language:Chinese
-
Abstract:
Single-cell RNA sequencing (scRNA-seq) can analyze the transcriptome of various tissues and organs at single cell level, identifying cellular subpopulation and intercellular heterogeneity to construct gene expression profile. Currently, scRNA-seq has been widely applied in central nervous system diseases, offering insights into disease pathogenesis, uncovering disease-related biomarkers, and identifying novel diagnostic and therapeutic targets. This review summarizes the recent advance in application of scRNA-seq in central nervous system diseases, aiming to provide new perspective for disease diagnosis and personalized treatment.
