From imaging penumbra to biological penumbra: insights into evolution of treatment concepts for acute ischemic stroke
10.3760/cma.j.cn115354-20241227-00814
- VernacularTitle:从影像学半暗带到生物学半暗带看急性缺血性脑卒中治疗理念的变更
- Author:
Lilan WANG
1
;
Qingwu YANG
1
Author Information
1. 陆军军医大学第二附属医院神经内科，重庆 400037
- Publication Type:Journal Article
- Keywords:
Acute ischemic stroke;
Ischemic penumbra;
Time window;
Tissue window
- From:
Chinese Journal of Neuromedicine
2025;24(3):217-223
- CountryChina
- Language:Chinese
-
Abstract:
Endovascular treatment is currently the most targeted therapeutic approach for acute ischemic stroke, which can recanalize the occluded blood vessels, restore the perfusion of ischemic penumbra, and reduce the size of infarct area. At present, evaluation of the ischemic penumbra mainly relies on imaging examinations; however, these examinations are difficult to fully reflect the cellular pathophysiological changes of brain tissues and lack unified standards; therefore, a more accurate method is urgently needed for evaluating the ischemic penumbra. This article summarizes the current dilemmas faced by imaging examinations in evaluating the ischemic penumbra and research status of biological markers in assessing the ischemic penumbra, proposing that volume of brain tissues that can be salvaged and biological markers as shown by imaging should be simultaneously focused during stroke treatment, so as to accurately evaluate the ischemic penumbra and improve the clinical prognosis to the greatest extent.
