Recent advance in NLRP3 inflammatome in neuropathic pain after spinal cord injury
10.3760/cma.j.cn115354-20240919-00582
- VernacularTitle:NLRP3炎症小体在脊髓损伤后神经病理性疼痛中的研究进展
- Author:
Simin CHEN
1
;
Hongyu QUAN
1
;
Mai LI
1
;
Qian CHEN
1
;
Ying WU
1
;
Yongmei LI
1
Author Information
1. 昆明医科大学第二附属医院康复医学科，昆明 650101
- Publication Type:Journal Article
- Keywords:
Spinal cord injury;
Neuropatic pain;
NLRP3 inflammasome
- From:
Chinese Journal of Neuromedicine
2025;24(1):94-99
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of neuropathic pain after spinal cord injury is still unclear, which might be closely related to ion channel changes, central sensitization and decreased function of descending inhibitory system after injury. Existing studies have shown that the nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3 (NLRP3) inflammasome play a key role in neuropathic pain after spinal cord injury; therefore, targeting NLRP3 inflammasome is a promising therapeutic strategy. This review analyzes the molecular mechanism and treatment of NLRP3 inflammasome in neuropathic pain after spinal cord injury, aiming to provide references for pathogenesis and treatment of neuropathic pain after spinal cord injury.
