Recent advance in angiogenesis mechanism and drug option of glioblastoma
10.3760/cma.j.cn115354-20241030-00662
- VernacularTitle:胶质母细胞瘤的血管生成机制及抗血管生成药物研究进展
- Author:
Hang YUAN
1
;
Xiuwei YAN
1
;
Shaoshan HU
1
Author Information
1. 浙江省人民医院神经外科，杭州 310016
- Publication Type:Journal Article
- Keywords:
Glioblastoma;
Angiogenesis;
Vascular endothelial growth factor
- From:
Chinese Journal of Neuromedicine
2025;24(1):88-93
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastoma (GBM) is one of the common malignant tumors in central nervous system, characterized by excessive angiogenesis. Anti-angiogenic therapeutic drug can improve the therapeutic effect on GBM by inhibiting angiogenesis. However, the mechanisms of angiogenesis in recurrent GBM differ from those in primary GBM, potentially bypassing the vascular endothelial growth factor (VEGF) pathway and forming new blood vessels through alternative routes, thereby the efficacy of anti-angiogenic drug is often poor in recurrent GBM. This review focuses on research progress in angiogenesis mechanism before and after GBM recurrence and provides references for GBM treatment.
