Efficacy and safety of intrasaccular flow disruptor in wide-necked intracranial aneurysms: a multicenter retrospective study
10.3760/cma.j.cn115354-20240922-00587
- VernacularTitle:瘤内扰流装置治疗颅内宽颈动脉瘤的多中心回顾性研究
- Author:
Xiaowen ZHANG
1
;
Jing LI
;
Xifeng LI
;
Chuanzhi DUAN
;
Aihua LIU
;
Huaizhang SHI
;
Haowen XU
;
Nan MA
;
Zhiqiang YAO
;
Feng FAN
;
Chao LIU
;
Jinyi LI
;
Hailong ZHONG
;
Mengyan FAN
;
Jiaxin WAN
;
Rijin LIN
;
Huixiang LIU
;
Jiamei ZHANG
;
Xin ZHANG
;
Sheng GUAN
Author Information
1. 郑州大学第一附属医院神经介入科，郑州 450052
- Publication Type:Journal Article
- Keywords:
Intracranial aneurysm;
wide-necked aneurysm;
Intrasaccular flow disruptor
- From:
Chinese Journal of Neuromedicine
2025;24(1):16-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of intrasaccular flow disruptor in wide-necked intracranial aneurysms.Methods:One hundred and seventeen patients with wide-necked intracranial aneurysms treated with intrasaccular flow disruptor were collected from Department of Neurointervention (First Affiliated Hospital of Zhengzhou University), Department of Neurosurgery (Beijing Tiantan Hospital, Capital Medical University), Department of Cerebrovascular Surgery, Neurosurgery Center (Zhujiang Hospital, Southern Medical University), and Department of Neurosurgery (First Affiliated Hospital of Harbin Medical University) from August 2022 to March 2024. Raymond-Roy Occlusion Classification (RROC) was employed to evaluate aneurysm embolization immediately after procedure; cranial CT or MRI within 48 hours of embolization were performed to identify any new intracranial hemorrhage, subarachnoid hemorrhage, or new symptomatic cerebral infarction related to the intracranial aneurysms. Modified Rankin Scale (mRS) was used to assess the neurological function at discharge. Imaging follow-up and outpatient follow-up were performed at 6 months after embolization to evaluate the aneurysm occlusion degree and complications.Results:A total of 117 intrasaccular flow disruptors were implanted in 117 patients, with a technical success rate of 100%; 115 patients (98.3%) enjoyed successful one-time release of their disruptors, and 2 patients (1.7%) required retrieval and redirection of the disruptors before second successful attempt. Flow disruptor plus stent was performed in 13 patients (11.1%). Immediately after procedure, RROC grading I was noted in 3 patients, grading II in 51 patients and grading III in 63 patients. Cranial CT or MRI within 48 hours of embolization indicated no new intracranial hemorrhage, subarachnoid hemorrhage, or symptomatic cerebral infarction related to the intracranial aneurysms. All patients had mRS score of 0 at discharge. Eighty-three patients completed a 6-month follow-up (RROC grading I in 41 patients, grading II in 33 patients and grading III in 9 patients), without ischemic or hemorrhagic adverse events.Conclusion:The results of this study preliminarily suggest that intrasaccular flow disruptor is effective and safe in wide-necked intracranial aneurysms.
