Research progress in the role of vascular smooth muscle cell phenotype switching and cell pyroptosis in abdominal aortic aneurysm

VernacularTitle:血管平滑肌细胞表型转换与细胞焦亡在腹主动脉瘤中的作用及研究进展
Author: Xin LIU ¹ ; Hongyue TANG ; Chang GUO ; Dong MA ; Mingming ZHANG
Author Information

1. 河北医科大学研究生学院,石家庄 050017;河北省人民医院临床医学研究中心,石家庄 050051;河北省代谢病重点实验室,石家庄 050051
Publication Type:Journal Article
Keywords: cell pyroptosis; phenotypic switch; atherosclerotic disease; abdominal aortic aneurysm
From: Chinese Journal of Comparative Medicine 2024;34(11):100-106
CountryChina
Language:Chinese
Abstract: Abdominal aortic aneurysm(AAA)is a hidden and fatal disease,but its underlying developmental mechanism remains unclear.Phenotypic switching of vascular smooth muscle cells and pyroptosis have been identified as biological processes closely related to the appearance and progression of AAA,with potentially important roles in the mechanism of AAA and in providing new directions for its diagnosis and treatment.In this review,we discuss phenotypic switching of vascular smooth muscle cells and the regulatory relationship between cell pyroptosis and AAA.