Research progress in the intervention of tryptophan metabolism in Alzheimer's disease

VernacularTitle:色氨酸代谢干预阿尔茨海默病的研究进展
Author: Cui WU ¹ ; Canwei LI ; Hairong ZHAO ; Zizhong YANG ; Pengfei GAO ; Yu ZHAO ; Chenggui ZHANG
Author Information

1. 大理大学云南省昆虫生物医药研发重点实验室,云南大理 671000;大理大学药学院,云南大理 671000;大理大学药用特种昆虫开发国家地方联合工程研究中心,云南大理 671000
Publication Type:Journal Article
Keywords: Alzheimer's disease; tryptophan metabolism; research progress
From: Chinese Journal of Comparative Medicine 2024;34(11):75-83
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)is a degenerative neurological disorder that can lead to cognitive decline,mental behavior abnormalities,and a reduced ability to undertake daily life activities.Tryptophan is an essential amino acid for the human body and is produced by three main metabolic pathways,namely kynurenine,5-hydroxytryptamine,and indole derivatives.Influencing the metabolites of tryptophan can ameliorate neuroinflammation in the brain and significantly improve cognitive ability,while the occurrence and development of AD are reduced.In this paper,we review the research literature on the use of tryptophan metabolism intervention in AD in the last 3 years from CNKI,PubMed,and other databases,and summarize its mechanism of action,with a view to providing a reference for further research on anti-AD drugs.