Clinical value analysis of different MRI measurement methods in evaluating the efficacy of neoadjuvant therapy for breast cancer
10.3969/j.issn.1006-5725.2025.14.005
- VernacularTitle:不同MRI测量方式评估乳腺癌新辅助治疗疗效的临床价值
- Author:
Yuling DUAN
1
;
Xuezhi ZHOU
;
Yongyi LI
;
Lixia MA
;
Desheng YANG
;
Jiao CHENG
;
Yan WU
;
Tao LIU
;
Guoyuan JIANG
;
Mei WANG
Author Information
1. 遵义医科大学第三附属医院(遵义市第一人民医院)乳甲外科(贵州遵义 563000)
- Publication Type:Journal Article
- Keywords:
breast cancer;
magnetic resonance imaging;
neoadjuvant chemotherapy;
3D volume measurement;
efficacy evaluation;
ROC curve
- From:
The Journal of Practical Medicine
2025;41(14):2152-2159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the diagnostic performance of three breast MRI measurement methods—RECIST 1.1,the optimal method,and three-dimensional(3D)volumetric assessment—in assessing the efficacy of neoadjuvant chemotherapy(NAC)in breast cancer patients,with the objective of identifying the most clinically practical approach.Methods A total of 110 breast cancer patients who underwent NAC followed by surgical treatment between 2019 and 2023 were included in the study.Breast magnetic resonance imaging(MRI)was conducted within one week before and after the completion of NAC.Tumor response was evaluated using RECIST 1.1 criteria,widely recognized as the optimal method,as well as 3D volume measurement.Pathological response was determined according to the Miller-Payne grading system.Sensitivity,specificity,accuracy,and the area under the receiver operating characteristic curve(AUC)were computed and compared using the DeLong test.Results The AUC values for RECIST 1.1,the optimal method,and 3D volumetric assessment were 0.768,0.795,and 0.883,respectively.The 3D volumetric assessment exhibited significantly better discriminative performance(P＜0.05),with the highest sensitivity(98.9％),specificity(77.8％),and accuracy(95.5％).Additionally,the optimal method demonstrated superior performance over RECIST 1.1 across multiple parameters.Conclusions 3D volumetric mea-surement demonstrates superior performance compared to RECIST 1.1 and the optimal method in evaluating the response to NAC,offering a more accurate and comprehensive assessment tool.Additionally,the optimal method shows advantages over RECIST 1.1 and may serve as a practical alternative in settings where 3D software is not available.
