Progress in the application of behavioral evaluation methods for animal models of chronic fatigue syndrome
10.3969/j.issn.1005-4847.2024.11.008
- VernacularTitle:近五年慢性疲劳综合征动物模型行为学评价方法应用进展
- Author:
Yuanyuan QU
1
;
Chuwen FENG
;
Weibo SUN
;
Zhongren SUN
;
Binbin LI
;
Jing LU
;
Yuying SHAO
;
Shuhao GUO
;
Tao CHEN
;
Tiansong YANG
Author Information
1. 黑龙江中医药大学附属第一医院,哈尔滨 150040;黑龙江省中医药信息学重点实验室,哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
chronic fatigue syndrome;
animal model;
model evaluation methods;
behavioral evaluation
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(11):1433-1444
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of chronic fatigue syndrome(CFS)has gradually increased in recent years.Although CFS can severely affect patient quality of life,its clinical diagnosis is easily overlooked.Elucidating the pathogenesis of CFS and treating it from both etiological and symptomatological perspectives are crucial for patient recovery;however,its unclear pathogenesis means that etiological treatment options are limited,and current treatments mainly focus on improving clinical symptoms.In this context,there is a need to establish and evaluate a suitable animal model.This article comprehensively integrates the diagnostic criteria of CFS and progress in related basic research.We also summarize the behavioral experimental method used to evaluate CFS models in basic research in the past 5 years and discuss these evaluations from the perspectives of general condition,fatigue state,cognitive function,emotional state,and pain degree.This review aims to present the current situation,expose problems,trigger reflection,and promote improvements in the behavioral evaluation of animal models of CFS.
