Research progress on the role of microglia efferocytosis in Alzheimer's disease
10.3969/j.issn.1671-7856.2024.11.020
- VernacularTitle:小胶质细胞胞葬在阿尔茨海默病中的作用研究进展
- Author:
Chiyuan MA
1
;
Xinzhi WANG
;
Xiangzhe LIU
;
Zhenzhen HAN
;
Ming GUO
;
Haofei LIU
;
Xiao LI
Author Information
1. 河南中医药大学第一附属医院脑病中心,郑州 450000;河南中医药大学第一临床医学院,郑州 450000
- Publication Type:Journal Article
- Keywords:
microglia;
efferocytosis;
Alzheimer's disease;
cognitive impairment;
neuroinflammation
- From:
Chinese Journal of Comparative Medicine
2024;34(11):163-168
- CountryChina
- Language:Chinese
-
Abstract:
Microglia efferocytosis,the process by which microglia phagocytose damaged and dead cells,has anti-inflammatory and pro-damage repair effects.Recent studies have shown that microglia efferocytosis plays a crucial role in the pathogenesis of Alzheimer's disease(AD)and may be a novel therapeutic target for AD.This paper reviews the relationship between microglia efferocytosis and AD pathogenesis and the potential of using efferocytosis-related molecules as therapeutic targets for AD.The aim of this review is to provide new ideas and approaches for the treatment of AD.
