Recent advance in regulated effect of microglial on AD pathology
10.3760/cma.j.cn115354-20241023-00643
- VernacularTitle:小胶质细胞调控对阿尔茨海默病病理影响的研究进展
- Author:
Manqing ZHANG
1
;
Yufei LAN
;
Lei LI
;
Huan ZHANG
;
Jiankun LU
;
Yaoyuan DONG
;
Xiaoya GAO
;
Chenyang WANG
;
Hongbo GUO
Author Information
1. 南方医科大学珠江医院神经外科中心，国家临床重点专科，脑血管病诊断与治疗教育部工程研究中心，广东省普通高校脑功能修复与再生重点实验室，广州 510282
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Microglia;
Neuroimmunity
- From:
Chinese Journal of Neuromedicine
2025;24(1):76-81
- CountryChina
- Language:Chinese
-
Abstract:
Microglia are specialized immune cells in the brain, primarily responsible for clearing debris and responding to inflammation. One of the pathological features of Alzheimer's disease (AD) is the extensive activation of immune system in the brain, and the dynamic changes and dysfunction of microglia could become key factors for AD progression. This article reviews the research progress of regulated effect of microglial on AD pathology, and summarizes its potential value in AD treatment, in order to provide theoretical basis for exploring new therapeutic strategies and intervention targets for AD.
