Research progress in the mechanism and role of key signaling pathways of the peroxisome proliferator-activated receptor γ gene in osteoarthritis
10.3969/j.issn.1671-7856.2024.11.018
- VernacularTitle:PPARγ基因在骨关节炎中作用机制及其关键信号通路作用的研究进展
- Author:
Jian ZHANG
1
;
Dong WANG
;
Tiantian QI
;
Liangbin WU
;
Qi YANG
;
Fei YU
Author Information
1. 北京大学深圳医院,广东 深圳 518036
- Publication Type:Journal Article
- Keywords:
PPARγ gene;
osteoarthritis;
joint tissues;
signaling pathway;
mechanism of action
- From:
Chinese Journal of Comparative Medicine
2024;34(11):145-152
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis(OA)is a chronic degenerative disease with a high incidence rate among middle-aged and elderly people.It can cause joint pain,deformity,and functional impairment,leading to a heavy burden on patients and their families.Peroxisome proliferator-activated receptor γ(PPARγ)is a recently discovered ligand-dependent transcriptional regulatory factor that can regulate fat and carbohydrate metabolism,inflammation,and immune processes.Research has shown that the PPARγ gene plays an important role in OA cartilage degeneration,synovitis inflammation,and adipose lesions,and can affect OA progression through signaling pathways such as the AMP-activated protein kinase,Wnt,and sirtuin 1 pathways.This review focuses on the role and mechanism of the PPARγ gene in OA,in relation to joint-related tissues and key signaling pathways.
