Recent advance in human brain organoid technology and its application in Alzheimer's disease
10.3760/cma.j.cn115354-20241103-00679
- VernacularTitle:人脑类器官技术及其在阿尔茨海默病中的应用研究进展
- Author:
Ran LI
1
;
Xiaobo HAN
Author Information
1. 济宁医学院精神卫生学院，济宁 272013
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Human brain organoid;
Disease modeling;
Artificial intelligence
- From:
Chinese Journal of Neuromedicine
2025;24(1):68-75
- CountryChina
- Language:Chinese
-
Abstract:
Human brain organoids are three-dimensional miniature brain tissue models cultured from human stem cells, containing a variety of nerve cells and specific spatial organization structures, which can simulate key features of human brain development. Faced with the difficulties of obtaining human brain tissues and inability of animal models in reflecting the disease characteristics, brain-like organ models with similarities to brain function and structure have become a valuable tool for studying AD. This article reviews the development of brain-like organ models and their application in AD, and discusses how emerging technologies can achieve breakthroughs in AD research through brain-like organ models, with the aim of providing new ideas for early diagnosis and treatment of AD.
