Research progress on hypoxic cell models
10.3969/j.issn.1671-7856.2024.11.017
- VernacularTitle:缺氧细胞模型的研究进展
- Author:
Jing LI
1
;
Dongyang XU
;
Changqing LI
;
Mengyao SU
;
Zhijuan WANG
;
Mingjun ZHAO
;
Jialong ZHAO
;
Junyi YANG
;
Qiaodie YANG
;
Longli KANG
Author Information
1. 西藏民族大学医学部基础医学院,陕西 咸阳 712082;西藏民族大学高原相关疾病分子遗传机制与干预研究重点实验室,陕西 咸阳 712082;西藏民族大学高原环境与疾病相关机理研究高校重点实验室,陕西 咸阳 712082
- Publication Type:Journal Article
- Keywords:
hypoxic cell;
physical hypoxia;
chemical hypoxia;
reoxygenation
- From:
Chinese Journal of Comparative Medicine
2024;34(11):132-144
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia is associated with the occurrence and development of many diseases in clinical settings.Cell hypoxia not only serves as a vital marker for disease advancement,but also plays a pivotal role in exacerbating the disease process,and improving tissue hypoxia may thus provide new strategies for the treatment of related diseases.Further investigation of these diseases at the cellular and molecular levels requires the establishment of a cellular hypoxia model.Current extensively employed hypoxic cell models can be categorized primarily into three types:chemical hypoxia,physical hypoxia,and glucose deprivation hypoxia models.This article reviews the various types of hypoxic cell models and scrutinizes their applications and limitations in disease research.
