Incidence of basal ganglia calcification and its risk factors in patients with acute ischemic stroke
10.3760/cma.j.cn115354-20241101-00674
- VernacularTitle:急性缺血性脑卒中基底节钙化发生率及危险因素研究
- Author:
Qiuju LI
1
;
Bin LIU
1
;
Fang YAN
1
;
Wenbo ZHANG
1
;
Yunyun ZHENG
1
;
Yuhui WANG
1
Author Information
1. 上海市浦东新区浦南医院神经内科，上海 200125
- Publication Type:Journal Article
- Keywords:
Acute ischemic stroke;
Basal ganglia calcification;
Influencing factor
- From:
Chinese Journal of Neuromedicine
2025;24(1):54-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the incidence of basal ganglia calcification (BGC), and risk factors for BGC in acute ischemic stroke (AIS) patients.Methods:A total of 730 patients with nervous system diseases hospitalized in Department of Neurology, Shanghai Punan Hospital of Pudong New Area from January 2023 to December 2023 were enrolled. These patients were divided into AIS group ( n=380) and non-AIS group ( n=350). Propensity score matching (PSM) was firstly used for 1:1 matching to eliminate the differences in baseline data of these patients; BGC incidence was compared between the two groups. Univariate and multivariate Logistic regression analyses were used to screen the independent risk factors for BGC in AIS patients. Results:After PSM, there were 251 patients in the AIS group and 251 patients in the non-AIS group. No significant difference was noted between the two groups in age, gender, histories of hypertension, diabetes, hyperlipidemia, coronary heart disease, smoking and drinking, ratio of previous stroke, and serum calcium, low-density lipoprotein cholesterol, homocysteine, uric acid, estimated glomerular filtration rate, or parathyroid hormone ( P>0.05). BGC incidence in the AIS group was 33.1% (83/251), with mild BGC in 55 patients (21.9%), moderate BGC in 19 patients (7.6%), and severe BGC in 9 patients (3.6%). BGC incidence in the AIS group was significantly higher than that in the non-AIS group (33.1% vs. 16.7%, P<0.05). Univariate and multivariate Logistic regression analyses showed that female ( OR=1.842, 95% CI: 1.021-3.324, P=0.043) and diabetes ( OR=1.953, 95% CI: 1.205-3.167, P=0.007) were independent risk factors for BGC in AIS patients. Conclusion:Compared with non-AIS patients, AIS patients trend to have BGC; female AIS patients with diabetes mellitus are more likely to have BGC.
