Role of astrocytes in traumatic brain injury and therapeutic strategies
- VernacularTitle:星形胶质细胞在创伤性脑损伤中的作用及治疗策略
- Author:
Yizhen HUANG
1
;
Hao CHENG
1
;
Haowei WANG
1
;
Qianyao ZHANG
1
;
Chengliang LUO
1
;
Xiaofeng ZENG
1
Author Information
- Publication Type:Journal Article
- Keywords: astrocytes; traumatic brain injury; mechanism of injury; therapeutic strategies
- From: Chinese Journal of Comparative Medicine 2024;34(11):84-90
- CountryChina
- Language:Chinese
- Abstract: Traumatic brain injury(TBI)is caused by the direct or indirect effects of external factors that result in structural or functional loss of brain tissue.Astrocytes are homeostatic cells in the central nervous system that proliferate and activate rapidly in the early stages of TBI.They then participate in a series of pathological processes,such as neuroinflammation,blood-brain barrier disruption,glial scarring,and excitotoxicity after injury,and thus play a crucial role in secondary neurological injury following TBI.This paper reviews the role of astrocytes in the repair of TBI damage,with the aim of providing new strategies for the prevention and treatment of TBI.
