Effect of surgical intervention on IVF/ICSI outcomes in patients with ovarian endometriosis
10.3969/j.issn.1006-5725.2025.14.012
- VernacularTitle:手术干预对卵巢型子宫内膜异位症患者IVF/ICSI助孕结局的影响
- Author:
Wenxia LIU
1
;
Rusi LUO
1
;
Fangfang LIANG
1
;
Xiaodan WANG
1
;
Yichun GUAN
1
Author Information
1. 郑州大学第三附属医院生殖医学科(河南郑州 450052)
- Publication Type:Journal Article
- Keywords:
endometriosis;
embryo transfer;
in vitro fertilization;
sperm injection;
clinical preg-nancy rate;
live birth rate
- From:
The Journal of Practical Medicine
2025;41(14):2204-2209
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of surgical intervention on IVF/ICSI assisted conception outcomes in patients with ovarian endometriosis(OEM).Methods OEM patients who underwent IVF/ICSI treat-ment at the Reproductive Center of the Third Affiliated Hospital of Zhengzhou University between January 1,2019 and February 1,2024 were selected,including 228 cases in the non-operated group before assisted conception(Group A)and 426 cases in the operated group before assisted conception(Group B),and the assisted concep-tion outcomes of the two groups were analysed.Results There were no statistically significant differences in female age,BMI,infertility years,infertility type,and basal FSH level between the two groups(P＞0.05).AMH level and basal AFC were higher in group A than in group B(P=0.003).There was no statistical difference in the application of ovulation induction programme,total number of Gn days and total amount of Gn between the two groups(P＞0.05),but the amount of Gn initiation in Group A was lower than that in Group B(P=0.011).Applying multiple linear regression to adjust for confounding factors,there was a statistical difference in the 2PN fertilization rate between Groups A and B(P=0.007),whereas there was no statistical difference in the number of eggs obtained,the rate of available embryos,the rate of high-quality embryos and the rate of blastocyst formation between the two groups(P＞0.05).After applying binary logistic regression to adjust for the influencing factors related to clinical pregnancy rate and live birth rate,the clinical pregnancy rate(aOR=-0.896,95％CI:0.540～1.488),live birth rate in the two groups(aOR=0.976,95％CI:0.589～1.620)remained statistically indistin-guishable.Conclusions Surgical intervention may further impair ovarian reserve function in patients with OEM,but does not appear to affect embryo quality or pregnancy outcome.Surgical treatment prior to assisted conception may improve fertilization rates in patients with OEM.
