Study on animal models of systemic lupus erythematosus

VernacularTitle:系统性红斑狼疮动物模型及研究进展
Author: Qin LAI ¹ ; Xue GUO ; Meiying WANG
Author Information

1. 广西中医药大学,南宁 530000;深圳大学第一附属医院风湿免疫科,深圳 518000;松山湖材料实验室,东莞 523808
Publication Type:Journal Article
Keywords: systemic lupus erythematosus; animal model; autoantibodies; mouse
From: Acta Laboratorium Animalis Scientia Sinica 2024;32(11):1493-1504
CountryChina
Language:Chinese
Abstract: Systemic lupus erythematosus(SLE)models are divided into four major categories:spontaneous,induced,humanized and gene knockout models.Lupus animal models are of great significance for studying the etiology,pathogenesis,and treatment of SLE.By reviewing and comparing various lupus animal models,we aim to elucidate the main features,advantages,and disadvantages of different types of SLE models.This review provides a reference for researchers aiming to select appropriate models for the exploring genetic and environmental factors,pathogenic mechanisms,and therapeutic modalities of SLE.