Analysis of dilated cardiomyopathy animal models based on clinical characteristics of traditional Chinese and Western medicines
10.3969/j.issn.1005-4847.2024.11.013
- VernacularTitle:基于中西医临床病证特点的扩张型心肌病动物模型分析
- Author:
Shiyi TAO
1
;
Lintong YU
;
Jun LI
;
Deshuang YANG
;
Jiayun WU
;
Li HUANG
;
Mingjing SHAO
;
Xuanchun HUANG
Author Information
1. 北京中医药大学,北京 100029;中国中医科学院广安门医院,北京 100053
- Publication Type:Journal Article
- Keywords:
dilated cardiomyopathy;
combination of Chinese traditional and Western medicine;
combination of disease and syndrome;
animal model
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(11):1482-1492
- CountryChina
- Language:Chinese
-
Abstract:
Dilated cardiomyopathy(DCM)is a common disease leading to heart failure,arrhythmia,and sudden death.The etiology of DCM is complex and diverse,and the mechanisms have not been fully elucidated.Conventional interventions have a limited ability to improve the prognosis of patients,who have a 10-year survival rate of less than 25％.This study aimed to summarize the construction and characteristics of a DCM animal model and evaluate the clinical compatibility of the model with traditional Chinese and Western medicines.Analysis was based on domestic and overseas research into DCM animal models,Western clinical diagnostic criteria,and traditional Chinese medicine syndrome differentiation.The DCM modeling method mainly involved gene editing,drug induction,immune induction,viral infection,and rapid pacing induction.Experimental animals included muroids,zebrafish,Drosophila,and pigs,of which mice and rats were most commonly used.Gene editing was the most commonly used method for modelling DCM,followed by doxorubicin-induction.In the literature,the experimental animals,drugs,single or cumulative doses,administration method,and modeling period used varied among studies involving DCM animal models.The level of clinical anastomosis according to traditional Chinese and Western medicines varied considerably,being generally lower in traditional Chinese medicine than Western medicine in the same model.In addition,the modeling standards for DCM animal models were mostly based on Western medicine theories.The differentiation of syndrome models and information collection for the four diagnoses have not been standardized and unified.In the future,stable and homogeneous animal models of high clinical consistency combining both disease and syndrome need to be established to provide a basis for DCM mechanism research and drug development.
