Assessment of peripapillary retinal and choroid thickness of tail-suspension rats by EDI-OCT
10.3760/cma.j.cn113854-20220402-00045
- VernacularTitle:EDI-OCT评估尾部悬吊大鼠视乳头周围视网膜和脉络膜厚度变化
- Author:
Hongwei ZHAO
1
;
Bin WU
;
Kan GUANGHAN
;
Yan ZHANG
;
Feilong SONG
;
Yanyan YANG
;
Zemin HUANG
;
Fei WANG
;
Lin SHI
;
Yubo GONG
;
Jun ZHAO
;
Ling LUO
Author Information
1. 战略支援部队特色医学中心眼科，北京 100101
- Publication Type:Journal Article
- Keywords:
Rats;
Weightlessness simulation;
Retina;
Choroid;
Tomography, optical coherence
- From:
Chinese Journal of Aerospace Medicine
2022;33(3):134-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the changes of peripapillary retinal and choroid thickness of tail-suspension rats in simulated weightless.Methods:Sixty rats were divided into 2 groups: control group (15 rats) and tail-suspension group (45 rats). The rats in tail-suspension group were tested by -30° tail suspension to simulate the effect of weightlessness for establishing model. The peripapillary retinal thickness of the rats were measured before and after 4- and 8-week tail suspension by enhanced depth imaging-optical coherence tomography (EDI-OCT). The choroid thickness of the rats were measured before and after 4-, 8-, 10-, and 12-week tail-suspension by EDI-OCT.Results:There was a significant difference in the peripapillary retinal thickness among the groups with different suspension time ( F=30.89, P<0.001), and the thickness showed a downward trend with the extension of the tail suspension time. After 8 weeks of tail-suspension, there was a significant difference in the peripapillary retinal thickness between the tail-suspension group and the control group ( t=5.73, P<0.001). After 4, 8, 10, and 12 weeks of tail-suspension, there were significant differences in the choroidal thickness of the rats between the tail-suspension group and the control group ( t=6.32, 12.78, 9.69, 6.39, all P<0.001); there was a significant difference in the choroidal thickness of the rats with different suspension time ( F=51.08, P<0.001). With the time of the tail suspension, the choroidal thickness and its changes compared with before tail suspension showed an upward trend, and reached peak after 8 weeks and then slightly decreased. Conclusions:With the extension of tail-suspension time, the changes of peripapillary retinal thickness of the tail-suspension rats generally show a downward trend, and the changes of choroidal thickness generally increased, and decreased slightly after reaching peak.
