Characteristics of Serum Immunoglobulin in Cronkhite-Canada Syndrome:A Single Center Retrospective Study
10.12376/j.issn.2097-0501.2025.02.007
- VernacularTitle:Cronkhite-Canada综合征的血清免疫球蛋白特征:单中心回顾性研究
- Author:
Shuang LIU
1
;
Chengzhu OU
;
Muhan LI
;
Qiushi XU
;
Yunfei ZHI
;
Xingfang ZHANG
;
Hao TANG
;
Tianming XU
;
Gechong RUAN
;
Ji LI
Author Information
1. 中国医学科学院北京协和医院变态(过敏)反应科,北京 100730
- Publication Type:Journal Article
- Keywords:
Cronkhite-Canada syndrome;
IgG4;
IgE;
immune dysfunction
- From:
JOURNAL OF RARE DISEASES
2025;4(2):194-201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics and clinical significance of serum immunoglob-ulins in patients with Cronkhite-Canada syndrome(CCS).Methods This retrospective study included CCS patients admitted to Peking Union Medical College Hospital from December 2009 to September 2024 who under-went serum immunoglobulin testing.Clinical manifestations and ancillary examination results were analyzed ret-rospectively.Results Fifty-two patients were included(male:36[69.2%],female:16[30.8%]),with median onset age of 60(54-64)years and median diagnostic delay of 5(3-12)months.Common manifesta-tions included diarrhea(86.5%),abdominal pain(40.4%),hematochezia(19.2%),weight loss(86.5%),nail malnutrition(100.0%),pigmentation(88.5%),hair loss(84.6%),and hypogeusia(69.2%).Serum IgG reduction occurred in 21 patients(50.0%),while total IgE elevation was observed in 20(71.4%).Elevated serum IgG4 levels were noted in 11 patients(23.4%),with no significant clinical differences between IgG4-elevated and normal groups.IgG4 levels showed no statistical difference between active(n=43)and remission(n=27)groups.The hair loss rate was significantly higher in the total IgE-ele-vated group than that in the normal total IgE group(P=0.0383).Conclusions CCS patients exhibit periph-eral blood immunoglobulin disorders,with elevated IgE levels correlating with hair loss.This suggests an im-mune-mediated mechanism may underlie hair loss in CCS.
