Effects of Tai Chi combined with transcranial direct current stimulation on P300 event-related potential in patients with mild cognitive impairment
10.3969/j.issn.1001-1242.2024.12.006
- VernacularTitle:基于事件相关电位探讨太极拳联合经颅直流电刺激对轻度认知障碍患者P300的影响
- Author:
Ying XU
1
;
Zhijie QIU
;
Jingfang ZHU
Author Information
1. 福建中医药大学康复产业研究院,福建省 福州市,350122
- Publication Type:Journal Article
- Keywords:
mild cognitive impairment;
Tai Chi;
transcranial direct current stimulation;
event-related potential;
P300
- From:
Chinese Journal of Rehabilitation Medicine
2024;39(12):1783-1789
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of 12 weeks of Tai Chi combined with transcranial direct current stimula-tion(tDCS)on cognitive functioning in patients with mild cognitive impairment(MCI)using event-related po-tential(ERP)-P300.Method:Seventy-nine patients with MCI were randomly divided into 4 groups:Tai Chi+tDCS group(n=20)received Tai Chi training combined with anodic tDCS;Tai Chi+sham tDCS group(n=20)received Tai Chi training combined with sham tDCS;walking+tDCS group(n=19)received walking training combined with tDCS;walking+sham tDCS group(n=20)received walking combined with sham tDCS group.The dura-tion of the intervention was 3 times per week,1 hour/session,for 12 weeks.All participants were assessed at baseline and 12 weeks for global cognitive function,memory,ERP-P300 wave amplitude and latency.Result:After 12 weeks of intervention,the MoCA score of Tai Chi+tDCS group were significantly higher than walking+sham tDCS group(P=0.009);the MQ score of Tai Chi+tDCS group were significantly high-er than Tai Chi+sham tDCS group(P=0.010),walking+tDCS group(P=0.004)and walking+sham tDCS group(P=0.008).P300 amplitudes at the Pz amplitude and Cz amplitude of Tai Chi+tDCS group were significantly higher than walking+sham tDCS group(P＜0.00l,P=0.001),the Fz amplitude of Tai Chi+tDCS group were significantly higher than walking+tDCS group(P=0.011)and walking+sham tDCS group(P=0.002).Partial correlation analysis showed that the change of MoCA score was correlated with the change of Fz amplitude(r=0.261,P=0.034).Conclusion:A 12-week intervention of Tai Chi combined with tDCS can improve the cognitive function and increase Pz amplitude,Fz amplitude,Cz amplitude in MCI patients,and the change of overall cognitive func-tion may be related to the change of Fz amplitude.
