Comparison of short-term outcomes and prognosis between laparoscopic and open surgery for large gastric gastrointestinal stromal tumors
10.13267/j.cnki.syzlzz.2025.048
- VernacularTitle:腹腔镜与开腹手术治疗大型胃来源胃肠间质瘤短期疗效和预后比较
- Author:
Linde SUN
1
;
Zelong YANG
1
;
Xiaochen QIU
1
;
Wentong XU
1
;
Xin WU
1
Author Information
1. 中国人民解放军总医院普通外科医学部,北京 100853
- Publication Type:Journal Article
- Keywords:
large gastrointestinal stromal tumor;
laparoscopy;
open surgery;
propensity score matching
- From:
Practical Oncology Journal
2025;40(4):315-320
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the short-term outcomes and long-term prognosis between laparoscopic and open surgery for large gastric gastrointestinal stromal tumors(GISTs).Methods A retrospective cohort study was conducted on 110 patients with large gastric GISTs who underwent surgical treatment in the medical department of general surgery,Chinese People's Liberation Army General Hospital,from January 2015 to December 2020.Among them,47 were males(42.73%)and 63 were females(57.28%),with a median age of 55 years.Patients were divided into the open surgery group(n=57)and the laparoscopic surgery group(n=53)based on the surgical approach.Pro-pensity score matching(PSM)was performed using a 1∶1 nearest-neighbor matching method,resulting in 34 patients in each group after matching.Short-term outcomes and long-term prognosis were compared between the two groups.Results After matching,the laparoscop-ic surgery group showed significantly better outcomes than the open surgery group in terms of drainage tube removal time,operative time,intraoperative blood loss,and postoperative hospital stay(all P<0.05).No significant differences were observed in nasogastric tube removal time,time to first flatus,or time to resuming oral intake(all P>0.05).The open surgery group had lower hospitalization cost compared to the laparoscopic surgery group(P<0.05).Regarding long-term survival,the 1-,3-,and 5-year disease-free survival(DFS)rates in the lapa-roscopic surgery group were 100%,88.1%,and 88.1%,respectively,while those in the open surgery group were 100%,94.1%,and 94.1%.The 1-,3-,and 5-year overall survival(OS)rates in the laparoscopic surgery group were 100%,100%,and 88.8%,respectively,compared to 100%,97.1%,and 94.7%in the open surgery group.No statistically significant differences were found in DFS and OS between the two groups(both P>0.05).Conclusions Laparoscopic resection of large gastric GISTs is safe and feasible,without increasing the risk of tumor recurrence,and achieves comparable efficacy to open surgery.However,its application should still be approached with caution.
