Dual role and new strategies of pyroptosis in cancer therapy
10.3969/j.issn.1006-5725.2024.23.022
- VernacularTitle:细胞焦亡在癌症治疗中的双重作用与新策略
- Author:
Xiao XIAO
1
;
Fangyi LONG
;
Gang WANG
Author Information
1. 四川省妇女儿童医院/成都医学院附属妇女儿童医院妇科(四川成都 610045)
- Publication Type:Journal Article
- Keywords:
pyroptosis;
cancer progression promotion;
tumor growth inhibition;
chemoradiotherapy sensitivity enhancement;
immune response modulation;
nanomedicine
- From:
The Journal of Practical Medicine
2024;40(23):3419-3426
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a form of programmed cell death with inflammatory characteristics,which has attracted wide attention in the biomedical field in recent years.Pyroptosis plays a crucial role in activating host defenses,promoting inflammatory responses,regulating immune responses,and influencing the tumor microenvi-ronment.In cancer research,the dual role of pyroptosis is particularly significant,which can both inhibit tumor growth and promote tumor development in certain instances.Furthermore,research on pyroptosis offers new per-spectives for cancer treatment,particularly in enhancing the efficacy of traditional chemoradiotherapy,boosting anti-tumor immune responses,and applying nanotherapeutic strategies.This article reviews the regulatory role of pyroptosis in cancer progression,as well as its theoretical basis and practical applications as a potential anti-cancer strategy,with the aim of providing new insights and directions for the development of cancer treatment strategies in the future.
