Correlative analysis of elevated serum creatinine and renal dysfunction in asymptomatic civil pilots (cadets)
10.3760/cma.j.cn113854-20200713-00105
- VernacularTitle:民航飞行（学）员无症状血肌酐升高者肾功能损害情况分析
- Author:
Hongyan CHEN
1
;
Zhanmin XU
1
;
Mosheng HU
1
;
Xiang FEI
1
;
Fei XIE
1
Author Information
1. 中国民用航空局民用航空医学中心空勤体检鉴定所，北京 100123
- Publication Type:Journal Article
- Keywords:
Kidney diseases;
Serum creatinine;
Cystatin C;
Civil pilots (flying cadets)
- From:
Chinese Journal of Aerospace Medicine
2021;32(3):129-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the diagnosis of renal function impairment as the serum creatinine (Scr) level raised in pilots by determining the glomerular filtration rate (GFR) ( 99mTc-GFR) through diethylene triamine pentaacetic acid (DTPA) renal dynamic imaging standard method and to compare the accuracy of determining simply elevated Scr between the diagnosing of cystatin C (Cys C) and GFR evaluation for flying personnel. Methods:In this study, pilots and pilot cadets whose Scr level was diagnosed raised twice in the physical examinations at Civil Aviation Medical Center of Civil Aviation Administration of China during 2018-2019 were selected as subjects. The GFR was calculated by the evaluation equations of Cockcroft-Gault creatinine clearance (CG-CCr) and the modification of diet in renal disease (MDRD-GFR) upon the averaged Scr level. Blood Cys C and 99mTc-GFR were examined. According to the examination results, they were divided into 99mTc-GFR normal group ( 99mTc-GFR≥90 ml/min) and 99mTc-GFR reduced group ( 99mTc-GFR<90 ml/min). Results:A total of 95 cases were enrolled, all male with an average age of (35.27±10.32) years. There were 59 cases with renal function impairment, accounting for 62.1%. The correlation coefficients r of Scr, MDRD-GFR, Cys C, CG-CCr and total kidney 99mTc-GFR were 0.218, 0.535, 0.808, 0.857, respectively. There were statistically significant differences in MDRD-GFR, CG-CCr and Cys C between normal and reduced 99mTc-GFR groups ( P<0.01). Conclusion:The percentage of renal impairment in simple Scr raised pilots is 62.1%. Besides 99mTc-GFR, Cys C and CG-CCr have good diagnostic accuracy and can be used as a supplementary examination item for the patients with elevated Scr.
