Research progress on the treatment of osteoarthritis with small molecules derived from traditional Chinese medicine:A review of literatures

VernacularTitle:中药小分子治疗骨关节炎的研究进展
Author: Gang DENG ¹ ; Lixin ZHU ; Jiasong GUO ; Yizhou XU
Author Information

1. 南方医科大学南方医院赣州医院运动医学科(江西赣州 341000)
Publication Type:Journal Article
Keywords: osteoarthritis; curcumin; atractylenolide; resveratrol
From: The Journal of Practical Medicine 2024;40(23):3389-3393
CountryChina
Language:Chinese
Abstract: Osteoarthritis(OA)is a prevalent chronic degenerative disease in clinical practice,posing significant health threats while lacking specific effective treatments.In recent years,an increasing number of small molecules derived from traditional Chinese medicine have been utilized in experimental studies and clinical treatment of OA.The utilization of these small molecules aligns to a certain extent with traditional Chinese medical theories related to OA treatment.Moreover,due to their well-defined chemical structures and the reproducibility of their effects,along with relatively well-understood mechanisms,these compounds are gaining growing attention in the fields of OA research and clinical practice.To advance this field's development,this article systematically reviews the therapeutic efficacy and underlying mechanisms of various small molecules used for treating OA including curcumin,atractylenolide,resveratrol etc.,aiming to provide relevant background information and insights for researchers and clinicians.