Impact and clinical potential of RNA modifications in the development and progression of renal cancer
10.3969/j.issn.1671-7856.2025.07.013
- VernacularTitle:RNA修饰对肾癌发生发展的影响及临床潜力
- Author:
Huiting YANG
1
;
Lu LU
;
Qian LI
;
Boyang LIU
;
Shenglan GAO
;
Bitang HUANG
;
Chunlong YANG
;
Qingjun PAN
Author Information
1. 广东医科大学附属医院检验医学中心,广东湛江 524001
- Publication Type:Journal Article
- Keywords:
RNA modifications;
renal cancer;
impact and molecular mechanism;
clinical diagnosis and treatment
- From:
Chinese Journal of Comparative Medicine
2025;35(7):128-147
- CountryChina
- Language:Chinese
-
Abstract:
Renal cancer is a common and increasingly prevalent malignancy with a complex pathogenesis influenced by genetics,smoking,and obesity.Current treatment mainly involves surgery with adjunctive chemotherapy,radiation,and immunotherapy,but high rates of recurrence and metastasis indicate its limited effectiveness,emphasizing the need for better therapeutic targets.Growing evidence indicates that epigenetic modifications,particularly RNA modifications,play a critical role in renal cancer development and progression.This review highlights recent advances in renal cancer epigenetics,focusing on RNA modifications such as N6-methyladenosine(m6 A),N7-methylguanosine(m7G),5-methylcytosine(m5C),N1-methyladenosine(m1A),adenosine-to-inosine(A-to-I),N6,2'-O-dimethyladenosine(m6Am),and N4-acetylcytidine(ac4C),along with their regulatory factors.It also explores the diagnostic and therapeutic potential of targeting RNA modifications and associated proteins.
