The therapeutic effect of Dangui Quyu Pill combined with acupuncture on adenomyosis
- VernacularTitle:丹归祛瘀丸联合针刺治疗子宫腺肌病的疗效观察
- Author:
Fangfang ZHU
1
;
Shida LI
1
;
Xiuying CHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: adenomyosis; zhen ci liao fa; CA-125 antigen; Dangui Quyu pill; CA199 antigen; vascular endothelial growth factors
- From: Tianjin Medical Journal 2025;53(7):765-769
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the therapeutic effect of Dangui Quyu Pill combined with acupuncture on adenomyosis(ADS)and its influences on serum levels of vascular endothelial growth factor(VEGF)and carbohydrate antigen 199 and 125(CA199,CA125).Methods A total of 120 ADS patients were randomly divided into the control group(treated with acupuncture)and the treatment group(treated with Dangui Quyu Pills combined with acupuncture),with 60 cases in each group.The degree of dysmenorrhea before treatment and 6 months after treatment was evaluated by Visual Analogue Scale(VAS).Traditional Chinese Medicine(TCM)syndrome score was conducted.Uterine volume was detected by color Doppler ultrasound on the day of enrollment and 6 months after treatment(avoiding the menstrual period).Levels of VEGF,CA199 and CA125 were detected by ELISA before treatment and 6 months after treatment.The adverse reactions and recurrence of patients were observed and recorded.Results The total effective rate was higher in the treatment group than that of the control group(P＜0.05).After treatment,the VAS score,TCM syndrome score,menstrual volume,uterine volume,serum levels of VEGF,CA199 and CA125 were lower in both groups than those before treatment,and the treatment group was even lower than those of the control group(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups,and the recurrence rate of the treatment group was lower than that of the control group(P＜0.05).Conclusion The combination of Dangui Quyu pill and acupuncture has obvious effect and high safety in the treatment of ADS.
