Clinical study of Cuofeng San in the treatment of anterior circulation cerebral infarction in patients with syndrome of wind and phlegm blocking collaterals
- VernacularTitle:撮风散加味治疗前循环脑梗死急性期风痰阻络证的临床研究
- Author:
Guoqing CHEN
1
;
Qin YAN
;
Mingjiu CHEN
;
Yunqin WANG
Author Information
- Publication Type:Journal Article
- Keywords: cerebral infarction; stroke; cerebrovascular circulation; cuofeng san; neuron specific enolase; S100 calcium binding protein B; monocyte chemoattractant protein-1; vascular endothelial cell cadherin
- From: Tianjin Medical Journal 2025;53(7):761-765
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the efficacy of Cuofeng San in the treatment of anterior circulation cerebral infarction(ACCI)of patients with syndrome of wind and phlegm blocking collaterals.Methods A total of 150 ACCI patients were collected in this study,and they were divided into the control group and the treatment group using a random number table method,with 75 cases in each group.The control group was given standardized intervention according to the stroke diagnosis and treatment guidelines,while the treatment group was treated with modified Cuofeng San on the basis of the control group.Both groups were treated continuously for 2 weeks.The treatment effects were compared between the two groups before and after treatment,including the National Institutes of Health Neurological Impairment Scale(NIHSS)score,Barthel Index(BI)score of daily activity ability,scores of syndrome of wind and phlegm blocking collaterals,serum levels of neuron specific enolase(NSE),S100 calcium binding protein B(S100B),monocyte chemoattractant protein-1(MCP-1)and vascular endothelial cell calcium binding protein(VE-cadherin).Results The total effective rate of ACCI patients was higher in the treatment group than that in the control group(93.3％vs.81.3％,P＜0.05).After 1 week and 2 weeks of treatment,the NIHSS score and wind phlegm obstruction syndrome score decreased in both groups compared to those before treatment,while the BI score increased,and the improvement was more significant in the treatment group(P＜0.05).After the end of the treatment course,serum levels of NSE,S100B,MCP-1 and VE-cadherin decreased compared to those before treatment,and the decrease was more significant in the treatment group(P＜0.05).Conclusion The modified Cuofeng San has a significant effect on the treatment of wind phlegm obstruction syndrome in patients with ACCI acute phase.It can improve neurological function and enhance daily activity ability.
