Glymphatic system and Parkinson's disease:current concepts,mechanisms,and therapeutic perspectives
10.3969/j.issn.1671-7856.2025.07.011
- VernacularTitle:脑类淋巴系统和帕金森病:当前概念-机制-治疗前景
- Author:
Jieli YANG
1
;
Rui LAN
;
Yong ZHANG
;
Chen TANG
Author Information
1. 河南中医药大学第一附属医院脑病科,郑州 450000;河南中医药大学第一临床医学院,郑州 450046
- Publication Type:Journal Article
- Keywords:
glymphatic system;
Parkinson's disease;
aquaporin-4;
α-synuclein;
meningeal lymphatic vessels;
diffusion tensor image analysis along the perivascular space
- From:
Chinese Journal of Comparative Medicine
2025;35(7):109-120
- CountryChina
- Language:Chinese
-
Abstract:
The glymphatic system is a recently discovered essential waste-clearance pathway in the central nervous system that plays a pivotal role in maintaining brain homeostasis.Growing evidence suggests that dysfunction of this system is closely associated with the pathogenesis of various neurodegenerative disorders;however,its precise mechanistic involvement in Parkinson's disease is poorly understood.This review systematically summarizes the structural and functional characteristics of the glymphatic system,provides an in-depth exploration of its potential role in Parkinson's disease pathophysiology,and synthesizes current research evidence on glymphatic system-targeted therapeutic strategies,with the aim of establishing a theoretical foundation for advancing the understanding of PD pathogenesis and developing novel diagnostic and therapeutic approaches.
