Correlation analysis of serum inflammatory factor level and renal function injury in patients with sepsis
10.3760/cma.j.cn115455-20231026-00391
- VernacularTitle:脓毒症患者血清炎性因子水平与肾功能损伤的相关性分析
- Author:
Feiyan WANG
1
;
Xiaokang JI
1
;
Zongxin XIA
1
Author Information
1. 上海市第六人民医院急诊医学科，上海 200233
- Publication Type:Journal Article
- Keywords:
Sepsis;
Renal insufficiency;
Procalcitonin;
C-reactive protein;
Interleukin-6
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(4):336-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between serum inflammatory factor level and renal function injury in patients with sepsis.Methods:A total of 102 patients with sepsis diagnosed and treated in Shanghai Sixth People′s Hospital from May 2021 to May 2022 were retrospectively selected as the study objects. According to whether renal function injury occurred, they were divided into renal function injury group (37 cases) and no renal function injury group (65 cases). Multivariate Logistic regression was used to analyze the risk factors of renal function injury in patients with sepsis, and Pearson test was used to analyze the correlation between inflammatory factor and renal function injury in patients with sepsis. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of procalcitonin (PCT), C-reactive protein (CRP) and interleukin 6 (IL-6) in patients with sepsis.Results:The results of multivariate Logistic regression analysis showed that Acute Physiological and Chronic Health Score System Ⅱ (APACHE Ⅱ) score, Sequential Organ Failure Assessment (SOFA) score, PCT, CRP, IL-6, blood urea nitrogen (BUN), 24 h urinary protein and serum creatinine (Scr) were risk factors for renal function injury in patients with sepsis ( P<0.05). The results of Pearson test showed that PCT, CRP and IL-6 were positively correlated with BUN, 24 h urinary protein and Scr of patients with sepsis ( r = 0.614, 0.622, 0.597, 0.672, 0.634, 0.611, 0.628, 0.589, 0.602, P<0.05). The results of ROC curve analysis showed that the area under the curve of PCT, CRP and IL-6 combined detection in patients diagnosed with sepsis was 0.879, and was higher than any single index ( P<0.05). Conclusions:The levels of PCT, CRP and IL-6 are increased in patients with sepsis, which has a certain impact on renal function, and has an important reference value for the evaluation of renal function injury in patients with sepsis.
