Laryngeal edema induced by flurbiprofen axetil
10.3760/cma.j.issn.1008﹣5734.2019.04.009
- VernacularTitle:氟比洛芬酯致喉头水肿
- Author:
Lirui SUN
1
;
Hongmei ZHANG
1
;
Qiushi GUO
1
;
Xu TIAN
1
;
Zhihui SUN
1
Author Information
1. 吉林大学第一医院二部药学部,长春,130031
- Publication Type:Journal Article
- Keywords:
Anaphylaxis;
Laryngeal edema;
Flurbiprofen axetil
- From:
Adverse Drug Reactions Journal
2019;21(4):290-291
- CountryChina
- Language:Chinese
-
Abstract:
A 35﹣year﹣old male patient received an IV infusion of flurbiprofen axetil 100 mg,which was diluted in 100 ml of 0. 9% sodium chloride injection,once daily for waist and abdomen persistent colic because of right ureteral calculi. The patient developed dyspnea,facial swelling,nasal obstruction,runny nose,and laryngeal edema after the first dose of flurbiprofen axetil infusion for about 20 minutes( infusion volume was about 50 ml). Flurbiprofen axetil allergy was considered. Flurbiprofen axetil was stopped immediately and anti﹣allergy treatments with adrenaline,dexamethasone,budesonide,and promethazine were given,accompanied with symptomatic supportive treatment with oxygen. About 30 minutes later,the patient′s dyspnea relieved and 3 hours later,the facial swelling,nasal obstruction,runny nose,and laryngeal edema disappeared. Then IV infusions of cefuroxime sodium and phloroglucinol were given and the patient′s waist and abdomen pain obviously improved 3 days later.
