Research progress on mechanism and treatment of N 2O 4 injury from rocket propellant
10.3760/cma.j.cn113854-20201231-00182
- VernacularTitle:液体火箭推进剂N 2O 4中毒机制及救治研究进展
- Author:
Huiqin CHEN
1
;
Shugen QU
;
Fajian LUO
;
Xumin ZONG
;
Yu TU
;
Jun WAN
Author Information
1. 苏州大学医学部放射医学与防护学院，苏州215123
- Publication Type:Journal Article
- Keywords:
Respiratory distress syndrome;
Poisoning;
Review;
Rocket propellant
- From:
Chinese Journal of Aerospace Medicine
2021;32(1):57-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the research progress on tissue damage, poisoning mechanism and treatment measures for the injury caused by liquid rocket propellant nitrogen tetroxide (N 2O 4) in China and foreign copuntries. Literature resource and selection The literatures published in the related fields at home and abroad. Literature quotation Fifty-one references were cited. Literature synthesis N 2O 4 is currently a commonly used liquid rocket propellant, which is a colorless gas or liquid and easy decomposition into nitrogen dioxide. It has the characteristics of flammability, explosive, strong oxidation and toxicity. In the process of propellant transportation and usage, poisoning and explosion accidents caused by N 2O 4 leakage occurred from time to time, which seriously threatened the physical and mental health of employees. Early inhalation of N 2O 4 may cause eye and respiratory tract irritation, and severe ones included pulmonary edema and acute respiratory distress syndrome. Long-term exposure may lead to idiopathic pulmonary fibrosis, and the difficulty of treatment N 2O 4 for poisoning patients was increasedwheninjured by the blast of the explosion at the same time. A large number of experimental studies have shown that vitamins E and radix salviaemiltiorrhizae (RSM) can reduce oxidative stress and inflammatory responses induced by N 2O 4. However, due to the lack of specific antidotes in actual treatment, symptomatic treatments such as oxygen administration and correction of pulmonary edema were often used. Conclusions:N 2O 4 poisoning can cause acute respiratory system damage, such as respiratory tract inflammation and pulmonary edema and also lead to chronic diseases, such as fibrosis or other organ damages. Symptomatic and supported treatment is often used in the process of treatment. It indicated that further study of N 2O 4is needed to clarify the molecular mechanism of its action, so as to provide help for clinical treatment.
